Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
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چکیده
منابع مشابه
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
Interleukin-23 (IL-23) is an inflammatory cytokine that plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. It orchestrates innate and T cell-mediated inflammatory pathways and can promote T helper 17 (Th17) cell responses. Utilizing a T cell transfer model, we showed that IL-23-dependent colitis did not require IL-17 secretion by T cells. Furthermore, IL-23-in...
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ژورنال
عنوان ژورنال: Immunity
سال: 2008
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2008.02.019